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Objectives: To review the high level evidence including systematic reviews and meta analyses on the role of oral products in the prevention and treatment of skin aging

Introduction: Several approaches have been used to prevent, delay and/or treat skin aging including topical, oral, chemical, physical, light and energy based devices, injections, and surgery. Oral products are attractive options as they are more convenient to use and may have higher compliance, but they should reach the skin in sufficient quantities to exert their actions. On the other hand, they should not accumulate in other tissues and produce side effects in long term use. They may have anti oxidant and anti inflammatory effects and/or stimulate fibroblasts.

Materials / method: The PubMed was searched for systematic reviews (SR) and meta analyses (MA) of randomized controlled trials - as the highest level of evidence- of anti-aging products.
Several oral products have been studied including water, retinoids (Isotretinoin), vitamins (C, E, A, D), carotenoids, polyphenols, fruits and plant extracts, hyaluronic acid, collagen, ceramides, fish oil, and probiotics.

Results: The available SRs and MAs provide strong evidence to support the efficacy of oral hydrolyzed collagen, polyphenols (such as Polypodium leucotomos), and carotenoids (mainly astaxanthines) in the increase of skin hydration and elasticity, improvement of skin barrier, reduction in skin wrinkles, and even prevention of skin cancers. There are also some evidence to suggest the use of drinking 1-2 liters daily water, fruit extracts and juices, ceramides and hyaluronic acid may improve skin aging.

Conclusion: Although medical journals, social media and are overwhelmed with oral products claiming anti aging properties, scientific evidence supporting their efficacy is limited. Further well designed, randomized, controlled trials on large sample size with long duration of treatment and follow up, assessing objective and important outcome parameters of skin aging such as wrinkles and skin cancers are necessary to provide solid evidence for recommending oral anti aging products.

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Objectives: The objective of this split-face study was to determine whether topical application of a novel multiple-active emulsion moisturizer before, during and up to 7 days after microneedling treatment can resolve inflammation and accelerate wound healing in adults with healthy skin to amplify luminosity and reduce erythema and tactile skin texture over 28 days, compared to conventional microneedling protocol with a hyaluronic acid serum vehicle control.

Introduction: Introduction: Microneedling is a cosmetic procedure that leverages the skin’s natural ability to heal in order to promote collagen formation and skin rejuvenation. To provide improved results, the technique can be combined with topical skin treatment formulations. A new formulation of multiple actives, including omega-3 (n-3) polyunsaturated fatty acids (PUFAs), was designed to accelerate the resolution of inflammation and wound healing following microinjury treatments, while enhancing the visible appearance of procedure results, including erythema, luminosity and skin texture.

Materials / method: In this randomized, controlled, split-face study, we examined 32 healthy female participants aged 30–70 years for 4 weeks following microneedling treatment with a novel, multiple-active aqueous formulation versus conventional microneedling protocol with a hyaluronic acid control serum. Changes in skin condition were assessed by blinded clinical photography and expert evaluation. Measurements were collected at baseline, 1 h, 1 day,7 days and 28 days post treatment.

Results: Significantly greater improvements in expert-assessed erythema, luminosity and skin texture were reported following application of the novel multiple-active-ingredient formulation than with the hyaluronic acid control serum. The data support topical application of a novel multiple-active-ingredient formulation in combination with microneedling for accelerating inflammation resolution and subsequent wound healing in female adults with healthy skin; however, further evaluation among adult male subjects with healthy skin is needed to ensure broader efficacy

Conclusion: These data provide new evidence for the role of a novel multiple-active-ingredient formulation for improving skin outcomes up to 28 days following microneedling in adults with healthy skin when compared with a hyaluronic acid serum. The n-3 PUFA content of this formulation may drive accelerated inflammation resolution and wound healing alongside the complementary action of the other active ingredients, leading to the observed improvements in erythema, luminosity and skin texture.

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请注明名称（个人，公司，学会等等）: Unilever

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请注明名称（个人，公司，学会等等）: Unilever

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这项工作的完成感谢以下机构的支持： Dermalogica