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Naked truth about exosomes and its implications in aesthetic medicine today - (ExoCoBio Inc. symposium)

Focus program

Room: Webinar
Date: Tuesday 6 July 2021 at 11:00 to 12:30
Format: INDUSTRY SYMPOSIUM > educational and promotional program conducted by the supporting company

Lectures of the session

Hours	Speakers	Lecture title	Abstract	Number
11:00	Dr Steven R COHEN	Facial regenerative medicine and potential role of exosome in aesthetic medicine	View	111846
11:15	Dr Tunc TIRYAKI	Research & clinical data on exosomes in aesthetic surgery: update		111847
11:30	Dr Diane Irvine DUNCAN	Application of lyophilized exosomes (derived from adipose stem cell) in aesthetic medicine		111848
11:45	Dr Inigo DE FELIPE Y GARATE	Exosomes in treatment of Androgenetic Alopecia (AGA)	View	111849
12:00		Q&A		111850

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Dr Steven R COHEN

Plastic Surgeon

United States

Other author(s) :

Facial regenerative medicine and potential role of exosome in aesthetic medicine

Objectives: 1. Present a brief history of regenerative medicine
2. Introduce a concept of dynamic facial age management
3. Discuss Nanofat, Stromal Vascular Fraction and introduce Exosomes

Introduction: Regenerative medicine was kickstarted in the early 2000's with the findings of stem cells and regenerative cells in fat. The promise of regenerative medicine has been to utilize the body's own repair mechanisms and the cells involved as therapies for numerous types of injuries and acquired disorders. Herein, I will outline a brief history of adipose derived stem and regenerative cells, the development of a proven technique of regenerative facial fat grafting and introduce the use of exosomes, which may turn out to be the most powerful biologic we have available to date.

Materials / method: The history of regenerative medicine will be briefly covered and an example of how regenerative medicine and exosomes can be applied in facial aesthetics will be discussed.

Results: Current prospective data on outcomes combining regenerative strategies with lasers and surgery will be presented as case examples of regenerative facial surgery.

Conclusion: New concepts in regenerative medicine have progressed to standardized treatment regimens that can be used as a template for new advances. Exosome therapies may ultimately represent the future of the regenerative medical field.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
Yes
Please specify entities (individual, company, society): ExCoBio- honorarium for this presentation

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
Yes
Please specify entities (individual, company, society): The Mage Group, UK (nanocube); MMT

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
Yes
Please specify date...: pending
and status : Patent on ITR2 anatomic and regenerative fat grafting

This work is presented thanks to the support of: ExCoBio

Dr Tunc TIRYAKI

Cosmetic Surgeon

Turkey

Other author(s) :

Research & clinical data on exosomes in aesthetic surgery: update

Dr Diane Irvine DUNCAN

Plastic Surgeon

United States

Other author(s) :

Application of lyophilized exosomes (derived from adipose stem cell) in aesthetic medicine

Dr Inigo DE FELIPE Y GARATE

Dermatologist

Spain

Other author(s) : De Vargas Machuca A, Lopez Sanchez C

Exosomes in treatment of Androgenetic Alopecia (AGA)

Objectives: We designed a randomized double-blind controlled study to assess the effects of Growth Factors contained in ASC-Exosomes added to conventional AGA treatment.

Introduction: Platelet Rich Plasma (PRP) has been used as a Growth Factors (GF) source in Androgenetic Alopecia (AGA). New sources of GF contained in stem cell-derived exosomes, and their role in AGA is still to be determined.

Materials / method: Methods:
80 male patients were diagnosed with AGA and received standard treatment with a daily intake of 5 mg Oral Minoxidil (OM), 0.5 mg Oral Dutasteride (OD), and 299 mg oral Saw Palmetto (SP). 40 were then randomly assigned to the ASC-Exosome group (EXO) and received additionally 6 sessions of scalp infiltrations per month with exosomes containing GF. The other 40 were randomly assigned to the Control group (sham or C) and received instead 6 sessions of saline solution infiltrations. Macroscopic pictures were taken at baseline and 12 months after treatment. Through trichoscopy pictures,

Results: All patients finished the treatment. At the 6 and 12 months evaluation, hair density in group C had overall increased by 14.4% and 16.7%, whereas patients in the EXO group had a hair density increase of 22.6% and 25.4% respectively. Terminal hairs increased 18% and 25% at 6 and 12 months respectively in the Control group and 27% and 36% respectively in the ASC-Exosome group.

Conclusion: Growth Factors and other Bioactive ingredients contained in ASC-Exosomes increase the density of hair in AGA with safety and should be considered as an adjuvant to conventional therapy with OD, OM, and SP in AGA.

Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): Exocobio

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

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IMCAS Academy International Program

Naked truth about exosomes and its implications in aesthetic medicine today - (*ExoCoBio Inc. symposium*)

Lectures of the session

IMCAS Academy International
Program

Naked truth about exosomes and its implications in aesthetic medicine today - (ExoCoBio Inc. symposium)