Objectives: The growth of the facial cosmetic industry reflects the increasing demand of patients seeking treatments to look younger. Combining facial procedures with topical skincare can provide optimal outcome for patients. We studied combination of a topical product designed to provide immediate soothing and increase hyaluronic acid levels in skin affecting texture and fine lines with neuromodulator injections which provide relief of dynamic facial wrinkles. The combination of the two would provide a better patient satisfaction and clinical outcome.
Introduction: Facial wrinkling has been shown to strongly correlate with one’s perceived age and is one of the key features of diminished skin quality due to photodamage and intrinsic aging, along with dyspigmentation and uneven skin texture. Neuromodulator injection procedures are an effective treatment for moderate-to-severe dynamic facial wrinkles, but do not address the static superficial fine lines and wrinkles caused by age-related loss of intrinsic hyaluronic acid levels in the epidermis.
Materials / method: In this study, the authors assess overall facial skin quality and patient satisfaction when combining topical treatment with a topical cosmetic serum (HA5) and applying to the entire face following a pre-elected neuromodulator injection treatment to the lateral canthal areas. Twenty female subjects aged 36 to 63 years with moderate-to-severe under-the-eye fine lines and/or wrinkles enrolled in the study. Clinical assessments were conducted at baseline; 15 minutes post-procedure; and at Weeks 2, 4, and 8.
Results: Immediately after treatment at baseline, a statistically significant improvement in fine lines and wrinkles in the periocular-lateral canthal area was observed. For the facial areas not treated by the neuromodulator injection, statistically significant improvements in the appearance of fine lines/wrinkles in the under-eye, forehead, and perioral facial areas were observed immediately after treatment at baseline. Long-term effects at Week 8 showed a statistically significant improvement of fine lines and wrinkles in all facial areas when compared with the same at baseline.
Conclusion: The combination of topical serum and injectable procedure provided a rapid onset of improvements in fine lines/wrinkles appearance and skin texture and long-term overall improvements in areas not treated by the injection. These results support how this novel combination can provide physicians with a comprehensive approach to optimize patient outcomes.
Disclosures
Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): Allergan Plc
Were you provided with any honoraria, payment or other compensation for your work on this study?
Yes
Please specify entities (individual, company, society): Allergan Plc
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work is presented thanks to the support of: Allergan Plc
