Objectives: The aim of this study is to clinically assess scar formation after three non-ablative fractional laser (NAFL)-exposures, targeting inflammation-, proliferation- and remodelling wound healing phases versus untreated controls.
Introduction: Within recent years, various lasers have been applied during wound healing to minimize scar formation. However, no consensus regarding treatment procedures exists.
Materials / method: A randomized, controlled trial was performed using a split-wound design to assess excisional wound-halves treated with 1540 nm NAFL versus no laser treatment. Three NAFL-exposures were provided respectively: immediately before surgery, at suture removal and six weeks after surgery. NAFL-exposures were applied using two hand-pieces, sequentially distributing energy deeply and more superficially in the skin (40-50mJ/microbeam). Evaluated at 3 months follow-up, primary outcome was blinded, on-site evaluation on Patient-Observer-Scar-Assessment-Scale (POSAS-total, range 6=normal skin to 60=worst i
Results: Thirty of 32 patients completed the trial. At three months follow-up, NAFL-treated scar halves showed improvement compared to untreated control halves on POSAS-total (NAFL-treated median 11[9-12] vs control median 12[10-16], P=.001). POSAS-subitems showed that NAFL-treated halves were significantly less red, more pliable, and presented with smoother relief compared to untreated controls.
Conclusion: In conclusion NAFL-treated scars showed improvement when compared to untreated control scars.
Disclosures
Did you receive any funding to support your research for this TOPIC?
No
Were you provided with any honoraria, payment or other compensation for your work on this study?
No
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work was not supported by any direct or non direct funding. It is under the author's own responsability