Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Our goal is to show that microfat, nanofat grafting can be effective in this indication. This study aims to present our technique, analyzing effectiveness, patient satisfaction, and complications.

Introduction: Genital restoration is growing in recent years. It can improve vaginal dryness, mucosa trophicity, genito-urinary symptoms of menopause (GSM) and loss of elasticity and volume of external genitalia.

Materials / method: Patients presenting vaginal trophic disorders, atrophy of labia majora, and GSM were included.
After abdominal fat harvesting (or internal face of the knees, or thighs) and fat graft preparation, a microfat and nanofat grafting was performed in the genital area.
8 ml of microfat was injected in the labia majora and 6 ml of nanofat in the vestibule, the G spot area and the first 3 centimeters of the vagina wall (posterior and lateral)
Fridmann score and Female Sexual Distress Scale (FSD) were used to evaluate the results, the effectiveness and tolerance of the treatment.

Results: 100 patients benefited from this technique. A significative improvement of the Fridmann score, pH, and FSD scale was found for all patients, with particular benefit on dryness, pH and dyspareunia.
No complication was found in our study.

Conclusion: This study demonstrate that functional disorders of intimate sphere can be treated by microfat, nanofat grafting.
This autologous procedure is able to provide a very good rejuvenation of genital area.
This method was effective in all patients and required a single session for long term benefit.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: - Know the up to date clinical evidence on fat grafting for critical wounds
- Know the up to date clinical evidence on adipose-derived stem cells (ASCs) for critical wounds

Introduction: Autologous fat grafting and stem cell therapy (SCT) are techniques that gained considerable interest in the recent years. On a scientific level the regenerative effect of autologous fat tissue and particularly adipose-derived stem cells (ASCs) is unquestioned as numerous experimental studies demonstrate. This being said the clinical evidence on fat grafting and therapy with ASCs in cutaneous wound repair remains sparse and thus inconclusive.

Materials / method: In this presentation, a closer look on clinical trials on fat grafting and ASC therapy for the treatment of critical wounds will be provided. Evaluated critical wounds include those after chronic radiation, pressure ulcers, diabetic ulcers, ulcers after systemic sclerosis, burn wounds, arterial and venous ulcers. Studies are reviewed regarding their technique of fat graft/ASC treatment, safety and clinical efficacy.

Results: The number of clinical trials on the efficacy of ASCs and particularly fat grafts on critical cutaneous wounds is limited. The applied techniques for fat graft processing and ASC isolation/culture vary considerably. Most of the clinical trials indicate a beneficial effect of fat grafts and ASCs on wound repair. Finally, fat grafting and ASC treatment of wounds appear to be safe procedures.

Conclusion: Based on the most recent literature, fat grafting and ASC application to chronic wounds appear to be safe procedure with mostly promising effects. However, fat grafting / ASC isolation protocols lack standardization and an increase in number of randomized clinical trials (RCTs) is highly desirable.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures