Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): research support

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: a) Know currently available sources for information on acne (most recent guidelines and reviews)
b) Know current treatment recommendations and underlying evidence

Introduction: Acne is one of the most frequent skin diseases. Many treatment options are available for the treatment of acne. But which treatment is the best for which acne type? What are the current treatment recommendations? For how long should the treatments be given and what recommendations are reasonable?

Materials / method: Extraction of key recommendations from current guidelines and systematic reviews.

Results: For comedonal acne, topical retinoids, azelaic acid or BPO are recommended. For mild to moderate papulopustular acne, fix combination treatments with adapalene and BPO or BPD and Clindamycin get the highest strength of recommendation. For severe papulopustular acne and conglabate acne, systemic isotretinoin received the highest strength of recommendation.

Conclusion: Different sources of information can be used to guide decision making. Current guidelines still favour medical / topical treatments. Light and laser treatments still have not gained a strong position in current guidelines.

Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): European Dermatology Forum

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work is presented thanks to the support of: European Dermatology Forum EDF

Objectives: Revision of the isotretinoin farmacocinetic and side effects as well as some of the most common concerns about their use in acne treatment.

Introduction: There are a before and after isotretinoin use in the history of acne treatment in terms of efficacy, results and scar sequela. Noneless, the side effects of the initial dose of more than 0,5 mg /Kg/day and the teratogenicity of the drug originated a plethora of myths, misjudgments and fears in both doctors and patients.

Materials / method: we revue the cientifical data, clinical cases and papers in PubMed and other medical sorces about: growing problems in children, suicidal and depression in teenagers, fertility and teratogenicity, doses and how long treated, inflamation rebound, interactions with other drugs and vitamin A, laboratory abnormalities and surveillance.

Results: Medium to low doses, simple lab controlling and, most of all, clinical supervision in consultation could make the difference in terms of results, side effects and patients compliance.

Conclusion: Oral isotretinoin is a drug with more than 30 years in the market and represents a milestone in acne history. Their use is very useful in moderate cases and a must in the severe ones. Besides teratogenicity, the majority of side effects are dose dependent and well minimised and controlled by doctors experienced in their use. Taking time with the patients to explain how to use it is crucial.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability