Objectives: - the general concept of the Butterfly Effect,
- the implications of the inflammatory character of acne and rosacea in the approach of the patients,
- the impact on the quality of life of acne and rosacea.
- the holistic and integrative approach to chronic inflammatory skin diseases.
Introduction: The butterfly effect represents the sensitive dependence on initial conditions. That is, a very small change in one state of a deterministic nonlinear system is associated with significant differences in a later state.
Edward Lorenz coined the term, and was derived from the metaphorical example in which the details of a tornado were influenced by minor perturbations such as the flapping of the wings of a distant butterfly. Lorenz discovered the effect when he observed that runs of his weather model with a minimal change in initial conditions had created a significantly different outcome.
Materials / method: Acne, characterized by androgen-induced increased sebum production, follicular hyperkeratinisation, inflammation and altered adaptive immune response, is a chronic inflammatory disease of the pilosebaceous unit with a critical negative impact on the quality of life.
Acne is characterized by a prolonged course, a pattern of recurrence or relapse, manifestation as acute outbreaks or slow onset, and a psychological and social impact that affects the individual’s quality of life, and now acne is considered to be a ”chronic disease”.
Results: Rosacea is a chronic and common skin condition characterized by specific signs and symptoms located mainly on the convex areas of the face, such as facial erythema, dilated vessels, inflammatory lesions (papules and pustules), hypertrophic lesions named phyma, sometimes accompanied by ocular irritation, with a potential important impact on the individual’s emotional wellbeing.
The pathophysiology of rosacea continues to remain unclear, and genetic factors, immune system dysregulation, abnormal neurovascular signaling and dysbiosis of commensal skin organisms may be the key promoters of rosacea
Conclusion: From the authors’ point of view, “the butterfly effect” associated with Acne and Rosacea is represented by education about these chronic inflammatory skin diseases, with emphasis on myths and skin care, because the power of false myths keep patients away from medical care; also, correct and individualized skin care is associated with a better adherence to treatment and results.
Dermatologists have the great opportunity to introduce dietary and metabolic interventions in acne so as to prevent more serious mTORC1-driven diseases of civilization like obesity, diabetes, and cancer.
Disclosures
Did you receive any funding to support your research for this TOPIC?
No
Were you provided with any honoraria, payment or other compensation for your work on this study?
No
Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No
Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No
This work was not supported by any direct or non direct funding. It is under the author's own responsability