Debraj SHOME's publications (32)

Orbital tuberculosis: a review of the literature.

2008

To provide an up-to-date review of the clinical presentations, investigations, and management of orbital tuberculosis (OTB). read more

Orbit (Amsterdam, Netherlands)

Community-acquired methicillin-resistant Staphylococcus aureus (CAMRSA)--a rare cause of fulminant orbital cellulitis.

2008

We report a 55-year-old female patient who developed a severe right-sided orbital cellulitis. Past history was significant for a boil on the right upper eyelid 2 days prior. Visual acuity at presentation was perception of light with inaccurate projection. Orbital computed tomography (CT) scan and routine blood investigations, including blood culture, urine examination, and urine culture, were performed. CT scan showed a superonasal orbital mass suggestive of an abscess. Abscess drainage followed by pus culture, sensitivity, and pulsed-field gel electrophoresis revealed community-acquired methicillin-resistant Staph…

Orbit (Amsterdam, Netherlands)

Carboplatin loaded polymethylmethacrylate nano-particles in an adjunctive role in retinoblastoma: an animal trial.

May, 2014

The purpose of the study is to compare the intra-vitreal concentrations of carboplatin, post peri-ocular injections of commercially available carboplatin (CAC) and a novel carboplatin loaded polymethylmethacrylate nanoparticulate carboplatin (NPC), in either eye, as a model system for treatment of advanced intra-ocular retinoblastoma (RB). read more

Indian journal of ophthalmology Load more  

In vivo intraocular distribution and safety of periocular nanoparticle carboplatin for treatment of advanced retinoblastoma in humans.

May, 2014

To study the intraocular distribution and safety of polymethylmethacrylate nanoparticles loaded with carboplatin after posterior subtenon injection in humans. read more

American journal of ophthalmology

Fungal keratitis with the type 1 Boston keratoprosthesis: early Indian experience.

Jul, 2012

To report 2 cases of fungal keratitis and endophthalmitis in patients with the type 1 Boston keratoprosthesis (KPro) in India. read more

Cornea

Botulinum toxin A: is it really that fragile a molecule?

Dec, 2010

Botulinum toxin A is considered to be an extremely fragile molecule, with recommended usage of some reconstituted botulinum toxin A formulations within 4 hours of reconstitution. Extreme caution is recommended to avoid agitation of the vial. read more

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Facial rejuvenation after intradermal botulinum toxin: is it really the botulinum toxin or is it the pricks?

Dec, 2010

The use of intradermal botulinum toxin A (onabotulinumtoxinA) remains a relatively new technique and is an off-label cosmetic application for facial skin rejuvenation. There is little documented clinical evidence of the objective benefits of this therapy. read more

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Recalcitrant fungal tunnel infection treated with intrastromal injection of voriconazole.

Dec, 2010

We are reporting a case of recalcitrant fungal tunnel infection treated with intrastromal injection of voriconazole. A 50-year-old woman underwent an uneventful phacoemulsification through a temporal corneal tunnel incision for age-related cataract in her right eye. One month post-surgery, she developed tunnel infection. Microbiological investigations revealed Aspergillus flavus as the offending pathogen. Despite intensive medical treatment, the corneal and anterior chamber infiltrate progressively enlarged. At the end of three and a half weeks, 0.1 ml of 0.05% voriconazole was injected intra-stromally surrounding the central end of the corneal infiltrate. On the subsequent follow-ups, a gradual improvement was noted and slowly it resolved completely. Topical therapy along with a judicious use of intrastromal administration of antifungal drugs may be of immense benefit in such cases prior to embarking on the surgical treatment. read more

International ophthalmology

Aspergillus keratitis in vernal shield ulcer--a case report and review.

Dec, 2010

An unusual case of vernal shield ulcer with superadded fungal keratitis caused by Aspergillus fumigates is reported. A 26-year-old man, a known case of vernal keratoconjunctivitis (VKC) presented with the complaint of diminution of vision in the right eye. Patient was on topical steroids and anti-allergic treatment for the past two months. In the right eye, a shield ulcer with an elevated plaque was seen. Scrapings from the right cornea revealed fungal filaments on a wet KOH mount and culture revealed growth of Aspergillus fumigatus. The patient was diagnosed as VKC with shield ulcer with secondary fungal keratitis. The patient was treated with topical cyclosporine, topical moxifloxacin, topical natamycin, and topical amphotericin eye drops. The patient responded well and finally recovered to a best spectacle-corrected visual acuity of 20/20 at the end of nine months. The chronic ocular surface changes and induced inflammation in VKC, and the instillation of topical steroids for therapy, may create an environmental milieu favorable for fungal keratitis. Microbiological evaluation should be considered, even in cases of suspected sterile keratitis, to prevent possible worsening of an associated infective corneal condition. This warrants patient education, periodic reviews and a very cautious approach to indiscriminate use of topical corticosteroids in cases of VKC with shield ulcer. In the event of any secondary fungal infection, use of steroid sparing topical agent, for example cyclosporine may be considered. read more

International ophthalmology

Implant and prosthesis movement after enucleation: a randomized controlled trial.

Aug, 2010

To evaluate implant and prosthesis movement after myoconjunctival enucleation and subsequent polymethyl methacrylate (PMMA) implantation, compared with the traditional enucleation with muscle imbrication using a PMMA implant and with enucleation accompanied by porous polyethylene implantation. read more

Ophthalmology

Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis.

Jun, 2010

To report a case of long-standing atopic dermatitis and atopic keratoconjunctivitis (AKC) with associated pellucid marginal corneal degeneration (PMCD). read more

Ocular immunology and inflammation

Flap buttonhole in thin-flap laser in situ keratomileusis: case series and review.

Jun, 2010

To analyze the clinical features and the risk factors leading to formation of flap buttonhole during laser in situ keratomileusis (LASIK) and the postablation visual outcome. read more

Cornea

Descemet's stripping endothelial keratoplasty: is it an option for congenital hereditary endothelial dystrophy?

Jun, 2010

The purpose of this study was to report our experience of an attempted Descemet's stripping automated endothelial keratoplasty (DSAEK) in a patient with congenital hereditary endothelial dystrophy (CHED). A 7-year-old boy presented with the complaints of decreased vision in his right eye. The left eye had undergone penetrating keratoplasty at the age of 5 years. He was diagnosed as a case of CHED, and a DSAEK was planned for him. Due to technical difficulties during Descemet's membrane scoring and stripping and poor visualization, the procedure had to be abandoned and converted to a full thickness penetrating keratoplasty. To the best of our knowledge, this is the first reported case of an attempted DSAEK in a patient with CHED. Proper DSAEK case selection should include adequate visualization of the endothelium and anterior chamber. Severe stromal haze and edema may prevent necessary surgical observation during the procedure, and a full thickness penetrating keratoplasty may be required. read more

International ophthalmology

Fungal keratitis associated with ocular rosacea.

Jun, 2010

In order to report fungal keratitis in patients of ocular rosacea, a retrospective review of all cases of fungal keratitis was undertaken. Cases in which ocular rosacea coexisted were identified and included in the study. The clinical course of patients thus identified was studied from the medical records and outcomes were evaluated. A total of three cases of fungal keratitis with coexisting ocular rosacea were identified. All three patients were known cases of acne rosacea with an intermittent, irregular treatment for the same. Previous history of contact lens use, ocular surgery or trauma was not present in any of the cases. Microbiological evaluation revealed Aspergillus flavus as the causative organism in two patients and an unidentified hyaline fungus in the third. Patients received simultaneous therapy for fungal keratitis and ocular rosacea. The ocular surface completely stabilized and the infiltrate resolved in all three cases. The chronic ocular surface changes and induced inflammation in ocular rosacea, along with the instillation of topical steroids for therapy, may create an environmental milieu favorable for fungal keratitis. Microbiological evaluation should be considered, even in cases of suspected sterile keratitis, prior to treatment with topical steroids, so as to prevent the possible worsening of an associated infective corneal condition. read more

International ophthalmology

Eyelid carcinoma in patients with systemic lymphoma.

Jan, 2010

To describe a series of patients with Non-Hodgkin's lymphoma (NHL) and concomitant eyelid carcinoma. read more

Journal of ophthalmic & vision research

Does a nanomolecule of Carboplatin injected periocularly help in attaining higher intravitreal concentrations?

Dec, 2009

To compare intravitreal concentration (VC) of commercially available carboplatin (CAC) and the novel nanomolecule carboplatin (NMC), after periocular injection. read more

Investigative ophthalmology & visual science

Targeted monoclonal antibody therapy and radioimmunotherapy for lymphoproliferative disorders of the ocular adnexa.

Sep, 2008

The goal of this review is to update ophthalmologists and orbital and adnexal specialists with the emerging role of targeted monoclonal antibody therapy and radioimmunotherapy for orbital and adnexal non-Hodgkin's lymphoma and other lymphoproliferative disorders of the orbit. read more

Current opinion in ophthalmology

Surgically induced necrotizing scleritis after pterygium surgery with conjunctival autograft.

Jul, 2008

To report a case of surgically induced necrotizing scleritis (SINS) as a complication of conjunctival autograft after pterygium excision. read more

Cornea

Nevirapine-induced Stevens-Johnson syndrome in an HIV patient.

Apr, 2008

To report a case of nevirapine-induced Stevens-Johnson syndrome (SJS) misdiagnosed as viral keratitis. read more

Cornea

Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine.

Mar, 2008

Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition. The authors describe a form of ulcerative keratitis in 5 patients with advanced gastrointestinal stromal tumor (GIST) enrolled in a phase I/II trial of perifosine in combination with imatinib. read more

Ophthalmology

Corneal bee sting misdiagnosed as viral keratitis.

Dec, 2007

To report a case of chronic keratouveitis caused by a missed bee sting injury. read more

Cornea

An unusual ocular manifestation in fanconi anaemia: anterior ischaemic syndrome.

Nov, 2007

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Eye (London, England)

Aspergillus-induced malignant glaucoma.

Jul, 2007

To report a case of Aspergillus flavus-induced keratomycotic malignant glaucoma. read more

Cornea

Scleral necrosis in a patient with aplastic anaemia.

Jul, 2007

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Eye (London, England)

Periosteal fixation in third nerve palsy.

Apr, 2007

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Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

Ptosis caused by orbicularis myokymia and treated with botulinum toxin: a case report.

Mar, 2007

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Eye (London, England)

Spectacle-induced ocular trauma: an unusual mechanism.

Jan, 2007

To report an unusual, spectacle-related injury. read more

Cornea

Choroidal ganglioneuroma in a patient with neurofibromatosis type 1: a case report.

Dec, 2006

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Eye (London, England)

Ocular surface squamous neoplasia in a renal transplant recipient on immunosuppressive therapy.

Dec, 2006

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Eye (London, England)

Bilateral epithelial defects after laser in situ keratomileusis. Clinical features, management and outcome.

Mar, 2005

To describe the preoperative characteristics, intraoperative details, management, and postoperative in patients with bilateral epithelial defects after laser in situ keratomileusis (LASIK). read more

Indian journal of ophthalmology

Thrombosed orbital varix -- a correlation between imaging studies and histopathology.

Mar, 2004

A thrombosed varix in the orbit is comparatively rare. Clinical examination alone is often inadequate for diagnosis. Radio-logical examination, such as a computed tomography (CT) scan of the orbit, is extremely important. Histopathological examination (HPE) after excision biopsy can confirm the diagnosis. The present authors describe a case of proptosis in the left eye of a 45-year-old man. CT-scan and HPE supported the diagnosis of a thrombosed orbital varix. This paper discusses the use of radiological investigations to supplement a clinical suspicion and make the diagnosis. This entity needs to be included in the differential diagnosis of proptosis and requires a coordinated approach for establishment of the diagnosis. read more

Orbit (Amsterdam, Netherlands)

Choroidal tubercles in disseminated tuberculosis diagnosed by the polymerase chain reaction of aqueous humor. A case report and review of the literature.

Dec, 2002

Disseminated tuberculosis occurs due to the hematogenous spread of pulmonary tuberculosis systemically. Polymerase chain reaction (PCR) of various body fluids has been found to be beneficial in the diagnosis of disseminated tuberculosis, including intraocular tuberculosis. We describe the role of PCR of the aqueous aspirate in a case of disseminated tuberculosis involving the choroid. read more

Ocular immunology and inflammation