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Dr Ludger KOLBE


Ludger Kolbe is the Chief Scientist for Photobiology at Beiersdorf, one of the major global companies for dermatological and cosmetic skin care.

Born in 1961, he graduated from the University of Münster, Germany, in biology and received a PhD for his research in immunobiology. During a postdoctoral training with Albert Kligman, MD, PhD, at the University of Pennsylvania in Philadelphia, he focused his research activities on experimental dermatology. Thereafter, he joined Beiersdorf Research & Development where he has held various positions in research on sensitive skin, inflammatory skin conditions, skin pigmentation and photobiology.

Currently, Dr. Kolbe directs the research on skin pigmentation and photoprotection. One of his key responsibilities is the identification of new protective mechanisms for dermatological and cosmetic skin care. This led to a multitude of international patents and original papers in scientific journals and the discovery of highly effective ingredients for topical skin care products. His current focus is on the development of treatments for UV-induced skin dyspigmentation and photoprotection.

Dr. Kolbe is member of the Society of Investigative Dermatology, the German Society for Immunology, the European Society for Photobiology and serves as a reviewer for various scientific journals. He also is a member of the Cosmetics Europe Expert Teams on Sun Protection and the ISO expert team for Sun Protection Methodology.

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Ludger KOLBE's publications (28)

High-energy visible light at ambient doses and intensities induces oxidative stress of skin-Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo.

Mar, 2020

Solar radiation causes skin damage through the generation of reactive oxygen species (ROS). While UV filters effectively reduce UV-induced ROS, they cannot prevent VIS-induced (400-760 nm) oxidative stress. Therefore, potent antioxidants are needed as additives to sunscreen products. read more

Photodermatology, photoimmunology & photomedicine

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma.

08, 2019

Melasma is a pigmentary disorder characterized by hyperpigmented patchy skin in sun-exposed areas, especially the face. Treatment of melasma can be challenging because long-term therapy is required, reoccurrence is common, and existing therapies are insufficient and unsatisfactory. To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study to assess the efficacy of the tyrosinase inhibitor Thiamidol compared to hydroquinone in women with mild to moderate melasma. After 12 weeks, modified Melasma Area and Severity Index scores significantly improved on both the Thiamidol-treated and the hydroquinone-treated sides of the face. Additionally, Thiamidol treatment improved modified Melasma Area and Severity Index scores significantly better than hydroquinone, and more subjects improved following treatment with Thiamidol (79%) compared with hydroquinone (61%). During treatment, no subjects displayed worsening of modified Melasma Area and Severity Index scores on the Thiamidol-treated side, while approximately 10% of the subjects showed a worsening of modified Melasma Area and Severity Index scores on the hydroquinone-treated side. All subjects routinely used sunscreens and consistent results were obtained in low and in high UV ambient conditions. Subjects rated the efficacy of the Thiamidol formulation significantly better with regard to overall decreased intensity of dark spots and their overall appearance throughout the study. Thiamidol was well-tolerated and well-perceived and represents an effective agent to reduce hyperpigmentation. read more

The Journal of investigative dermatology

Anti-inflammatory / anti-oxidant activity of ingredients of sunscreen products? Implications for SPF.

Jun, 2019

The Sun Protection Factor (SPF) of sunscreen products is derived from testing in vivo their ability to prevent erythema ("sunburn"). Recently, certain articles have raised concerns that sunscreen products may actively suppress erythema via anti-inflammatory / anti-oxidant (AI/AO) activity. These articles reason that this may result in a higher labelled SPF value than that provided by the efficacy of the UVR filters alone, giving consumers a "false sense of security". On the other hand, since inflammatory processes are known to play a role in the mechanisms of photodamage / skin cancer induction and propagation, AI/AO activity may provide valuable incremental photoprotective benefit (provided that there is no interference with visible erythema). The objective of these studies, therefore, was to investigate the potential of AI/AO ingredients to suppress UVR-induced erythemal response in human skin, in vivo. read more

International journal of cosmetic science
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