Objectives: Objectives:
1.To evaluate the result of vulvovaginal rejuvenation by using combination treatment of vaginal co2 laser and exosome
2.To evaluate safety of plant stem cell-derived exosomes for vulvovaginal rejuvenation

Introduction: Nowadays all age women concern about genital wellness.The aim of vulvovaginal rejuvenation is not only for aesthetics but also for functional and sexual function problems.Vaginal Co2 laser has been use for many years for improve vaginal laxity, SUI,Vaginal dryness.Exosomes are the most important mediators for intercellular communication. The triple functions of regeneration, rejuvenation, and anti-inflammation of exosomes have been well-known number of research. Exosomes are being developed as next-generation regenerative therapeutics and aesthetics to improve the quality of life of all women

Materials / method: 1. Evaluate VHI before treatment
2. Apply the numbing cream 45 minute at vulvar area
3. Use Co2 laser for vulvovaginal rejuvenation intravaginal and vulvar area
4. Apply the exosome intravaginal and vulvar area. Gentle message until exosome was absorbed
5. Follow the protocol of vaginal Co2 laser, 3 sessions, 4 weeks apart for 1st and 2nd session and 6 weeks apart for 3rd session

Results: Results:
1.Youthful appearance of vulvar area
2.Improve in vaginal dryness, tightening, improve in SUI
3.Improve in VHI
4.Not seen any complication

Conclusion: Combined treatment of vaginal Co2 laser and exosome for vulvovaginal rejuvenation improve in aesthetic and functional aspect. Patient satisfy with the results and not seen any complication

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: Labioplasty while offering substantial benefits in terms of aesthetic and functional improvements, is accompanied by a spectrum of potential complications.
We will discuss that complications such as infections, scarring, dyspareunia, and cosmetic dissatisfaction are relatively common but manageable with proper care and protocols. If the technique matters to avoid complication