Objectives: Background
Transdermal therapeutics delivery has great advantages for dermatological therapy. We have been used liposomes as carriers can provide a high transdermal effect. Liposomes formed lipid bilayer with natural phospholipids are biologically inert and weakly immunogenic, and they possess low intrinsic toxicity.
Introduction: In this study, we have used CO2 Fractional Laser as percutaneous absorption device, liposomes as transdermal carrier, and by a combination of them, aimed at improving the skin permeability of CF, OVA-FITC. Next, to develop temperature-responsive (TR) liposomes to achieve temperature-dependent, controlled release of encapsulated drug, and use fractional laser irradiation to enhance transdermal permeability of these liposomes.
Materials / method: We aimed to develop a percutaneous absorptive preparation that enables controlled release of internal capsule by temperature and increased skin permeability by using temperature responsive liposome modified with temperature responsive polymer to liposome.
Results: On laser irradiated skin, the transmittance was greatly increased as compared with unirradiated skin, and a response of permeability by power was confirmed
From the results of cell experiments, cell uptake was greatly improved by encapsulating OVA in liposomes
The skin permeability of unmodified liposomes was higher than that of polymers modified with polymers
Unmodified liposomes are thought to have lipids adsorbed / fused to the epidermis and permeated, and polymer-modified liposomes are permeated after release of the inner seal in solution.
Conclusion: By using liposomes and laser in combination, cell uptake of peptide and improvement and control of skin permeability became possible, and We think this research is a useful concept.
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