Objectives: To understand that not all biostimulators are regenerative. A physiological explanation of how they differ and why.

(This talk has been requested by Atchima Suwanchinda)

Objectives: We look into the multiple technologies and treatments available in the market and looking into the new definition of Regenerative Aesthetics

Objectives: the following two trendy topics in the field of biostimulators
(1) the debate of inflammatory vs. non-inflammatory biostimulators (PLLA-SCA vs. CaHA-R)
(2) the factors that affect in vitro studies of PLA and fibroblasts, based on review and comparison of several published studies

Introduction: (1) there's been a debate on the mechanism of how biostimulators induces neocollagenesis, with publication indicating that CaHA-R being non-inflammatory and PLLA-SCA being inflammatory, and vice versa. We all agree that too much inflammation is bad, but how do we decide how much is too much?
(2) Many factors affect the efficacy of collagen stimulation of in vitro fibroblast culture with PLA, including PLA size/shape/concentration, culture duration, presence of macrophages, senescence of fibroblasts/macrophages. Physicians have to be aware of these factors when interpreting these studies.

Materials / method: Review of literature and comparison/analysis

Results: (1) There's no definite answer yet as to which biostimulator is more inflammatory, and how much inflammation is too much. The answer probably also depends on the frequency, dosage, and host factors.
(2) Small-particle PLA (diameter < 1 um) may also induce transient neocollagensis with the presence of macrophages.
(3) It takes time for large-particle PLA (eg,. PLLA-SCA) to affect fibroblasts an cause collagen stimulation
(4) senescnet fibroblasts react differently with young fibroblasdts in in-vitro studies

Conclusion: More and more biostimulators enter the market, and physicians should be familiar with mechanisms of different products

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: This study aimed to investigate the interest and efficacy of combining nanofat grafting with hybrid cooperative complexes of high and low molecular weight hyaluronans, energy-based devices, and exosomes.

Objectives: Stretch marks on the abdomen were treated using a needle-less syringe. The effect was very good, and it was faster, more accurate, and more effective than manual injection.
To evaluate the effectiveness, histological changes, and collagen quality of CaHA filler injections for treating abdominal stretch marks using the needle-free injector.

Introduction: Stretch marks post-pregnancy are a common concern. This study investigates the use of CaHA filler injections with the CureJet needle-free injector to enhance collagen regeneration in stretch marks. The CureJet device uses magnetic power to deliver injections at a rate of 10 injections per second, ensuring consistent and precise injection depth.

Materials / method: 25 women with abdominal stretch marks received CaHA filler injections (1.5cc Radiesse + 15cc saline) monthly for three sessions using the CureJet needle-free injector. The diluted CaHA solution was frequently shaken during the injection process to ensure even distribution. The CureJet device, utilizing magnetic power, delivers injections at a rate of 10 injections per second, providing consistent and precise injection depth.
After injection, skin roughness was measured.

Results: Data analysis will include pre- and post-treatment skin roughness comparisons, dermal thickness via ultrasound, and histological evaluations. These assessments will provide insights into the effectiveness of the treatments and the quality of collagen regeneration.

Conclusion: This study aims to provide scientific evidence on the effectiveness of CaHA filler injections for abdominal stretch marks using the needle-free injector.
Findings will highlight improvements in scar appearance and collagen formation, offering valuable data for optimizing stretch mark treatment strategies.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability