Objectives: 1. Review the Latest Advances in Acne Scar Revision Techniques – Identify and explain the most recent innovations in surgical, laser-based, and regenerative treatments for acne scars, including emerging technologies and evidence-based approaches.
2. Differentiate Treatment Modalities Based on Scar Type and Patient Factors – Assess the appropriate treatment strategies for various acne scar types (atrophic, hypertrophic, post-inflammatory pigmentation) while considering patient-specific variables
3. Optimize Treatment Outcomes Through Combinations

Objectives: Hypertrophic scars, keloids, atrophic scars are common dermatological concerns that can significantly impact patients' quality of life. Recent advancements in the understanding of polynucleotides have opened new avenues for effective management and prevention of these scar types. Polynucleotides, with their regenerative properties, promote cellular proliferation, collagen synthesis, and tissue remodeling, thereby enhancing the healing process, reducing scar formation and improving the appearance of existing scars.

Objectives: Recognize correct indications for the treatment of scars, contractures and other sequelae after the treatment of burn injuries

Learn potential surgical and regenerative techniques for the treatment of aforementioned sequelae

Objectives: Botulinum toxin has emerged as a novel approach for keloid modulation, offering longer symptom-free intervals compared to steroids alone. It plays a valuable role in keloid management, particularly in prolonging symptom-free intervals beyond what steroids alone can achieve. While mechanistic evidence and clinical studies support its efficacy, personalized treatment plans and multimodal approaches are essential for maximizing patient outcomes and reducing recurrence risks.

Objectives: To present a novel method for treating acne scars using diluted calcium hydroxylapatite (CaHA) delivered via a needle-free injector. Attendees will learn about this technique’s efficacy, precision, and ability to stimulate collagen and dermal remodeling, with biopsy and ultrasound findings supporting enhanced tissue regeneration.

Introduction: Acne scars are challenging to treat with conventional methods. CaHA fillers are known for stimulating neocollagenesis. This study explores the effectiveness of delivering micro-droplets of diluted CaHA into the dermis using a needle-free injector to promote collagen production, scar elevation, and skin regeneration.

Materials / method: 30 patients with atrophic acne scars received CaHA diluted 1:10 via a needle-free injector. Each session delivered 2,000–3,000 micro-injections over 5 minutes. Scar depth was measured using sonography and 3D imaging. Biopsies were taken from consenting patients to evaluate collagen synthesis and stem cell markers (CD31, CD34).

Results: Patients showed significant improvement in scar depression and skin texture. Sonography confirmed accurate intradermal CaHA deposition. Biopsy revealed increased fibroblast activity, collagen, elastin, and vascularity. CD31 and CD34 expression increased by 68.5% and 59.2%, respectively. Active acne also improved without recurrence.

Conclusion: Needle-free injection of diluted CaHA is a safe and effective treatment for acne scars, combining precision delivery with regenerative stimulation. It improves dermal quality, enhances collagen production, and promotes stem cell activation, offering a promising alternative to laser or microneedle-based approaches.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability