Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: To explore new applications of Nanofat and MSC and ASC exosomes in inflammatory and immune Alopecia

Introduction: Mesenchymal stem cells (MSC) and Adipocyte derived stem cells (ASC) are the basis of regenerative medicine through Nanofat transfer and through signaling between cells via exosomes.
Some of these substances include micro-RNA known to have anti-inflammatory properties.

Materials / method: We have used MSC exosomes in 175 patients with Alopecia conditions such as Androgenetic Alopecia both in men and women, Lichen plano-pilaris, Frontal fibrosing alopecia, and Alopecia Areata. MSC Exosomes were injected alone or in combination with Nanofat and other drugs intradermally, applied topically or applied on skin treated previously with microneedling or Er:YAG fractional session.

Results: We show herein the results obtained in these skin conditions and discuss the probable mechanism of action.

Conclusion: Promising results can be obtained with Nanofat and MSC exosomes. These procedures are very safe.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: There has always been a quest to develop newer therapies for hair loss including AGA. Many therapies including topical finasteride, LLLL, PRP, Mesotherapy, Stem cell therapy, peptides have been tried and all have shown promise in various studies. Mesotherapy and stem cell micrografting has particularly evolved in the recent past and has shown promise

WE have been working on transfer of autologous stem cells, derived from the the patient's skin, to the balding areas for induction of hair growth

Introduction: Over thousands of years, Scientists have worked to establish various treatment modalities in Healthcare services. In 18th century, They revealed that all life depends on chemical reactions that occur within cells, which could, in fact, be reproduced in the laboratory. The discovery of cell division and heritability in the form DNA was geared to bring ‘a whole other ball game of Stem cell and Regenerative treatments.
Regenerative medicine has grown to extent of Cell therapy, Surgical implants & skin grafts.

Materials / method: In this study 2.5 mm punch grafts taken from the reteroauricular areas were subjected to intense crushing in a special chamber of the Rigenera machine. This machine rotates at a speed of 80 revolutions per min and the special perforated base and the blades break down the the skin into a fine paste that contains the stem cells derived from the hair follicle and the adipose tissue in the punches. this is suspended in normal saline and the final solution is injected into the balding area using the deep mesotherapy technique.

Results: Most of thje patients of grade II to III stage AGA did quite well and had a good stimulation of hair growth within 2 to 3 months of the procedure. The effects were sustained for upto one and a half year in most of the patients.

Needless to mention that the medical treatment was continued in most of these patients during and after the procedure.

Conclusion: In this era of dearth of certified and effective therapies for androgenetic alopecia where we have just oral finasteride and topical minoxidil as approved drugs by the USFDA, there is a huge requirement for development of newer therapies

Autologous stem cell therapy has come as a welcome boon for these patients and for the hair physicians for better management of this difficult and lifelong hair disorder.

This can be a great adjunct to the medical treatment of AGA

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability